FGF21

Across TCGA pan-cancer cohorts, FGF21 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FGF21 data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FGF21 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FGF21 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where FGF21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	1.000	0.771	.005	12	view →
PDAC	DFS	Median	III,IV	0.975	0.439	.024	5	view →
LUAD	DFS	Median	III,IV	0.305	0.920	.010	3	view →
HNSC	OS	Median	II,III,IV	0.876	0.661	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FGF21–UCEC (DFS)

Open the UCEC breakdown →