FGF18

Across TCGA patient cohorts, FGF18 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF18-associated genes across cancer lineages are p38-MAPK_pT180_Y182, STAT3_pY705, and DJ-1. Each is linked with FGF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF18-to-partner and partner-to-FGF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by FGF18-low versus FGF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF18→partner) and Y-score (partner→FGF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.510	-2.986	.049	.037	3	1
UCEC	STAT3_pY705 →	-0.410	-2.990	.006	.036	3	1
UCEC	DJ-1 →	-0.193	-3.000	.045	.037	3	1
UCEC	PDCD4 →	-0.861	-3.000	.001	.037	2	1
UCEC	Caspase-8 →	-0.333	-3.000	.021	.036	2	1
UCEC	EGFR_pY1068 →	-0.298	-3.000	.040	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

p38-MAPK_pT180_Y182 by FGF18 expression — UCEC

Explore this box plot interactively →