FGF18

Across TCGA pan-cancer cohorts, FGF18 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FGF18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FGF18 RNA is repressed in tumor relative to normal tissue. In most cancer types FGF18 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where FGF18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−2.018	<.001	9	view →
COAD	Female	All	+1.192	<.001	9	view →
LUAD	Female	III,IV	−1.547	<.001	8	view →
LUSC	Female	All	−1.873	<.001	7	view →
KIRC	Male	II,III,IV	−0.735	<.001	7	view →
UCEC	All	II,III,IV	+3.407	<.001	6	view →
HNSC	Male	All	−0.798	.001	4	view →
BLCA	Male	All	−0.777	.007	3	view →
KIRP	All	All	−0.555	.003	2	view →
BRCA	Female	All	+0.307	.008	2	view →
STAD	Male	IV	+1.290	.047	1	view →
READ	All	All	+1.182	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FGF18–KICH

Open the KICH breakdown →