FGF18

Across TCGA cell cohorts, FGF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,991 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible FGF18-associated GO terms across cancer lineages are Regulation of double-strand break repair, Negative regulation of complement-dependent cytotoxicity, and RNA polymerase II preinitiation complex assembly. Each is linked with FGF18 in more than 7 cancer types. Because this analysis shows association rather than direction, both FGF18-to-partner and partner-to-FGF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by FGF18-low versus FGF18-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF18→partner) and Y-score (partner→FGF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of double-strand break repair →	+0.049	+0.090	<.001	<.001	3	8
URINARY_TRACT	Negative regulation of complement-dependent cytotoxicity →	+0.168	+0.232	.003	.004	3	8
SKIN	RNA polymerase II preinitiation complex assembly →	+0.031	+0.084	.002	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Protein transmembrane transport →	+0.050	+0.208	.007	.007	2	7
OVARY	Adenylate cyclase-activating G protein-coupled receptor signaling pathway →	-0.063	-2.762	<.001	<.001	3	6
BLOOD_Leukemia	Positive regulation of double-strand break repair via homologous recombination →	+0.050	+0.066	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,991 associations by consensus.

Regulation of double-strand break repair by FGF18 expression — BLOOD_Leukemia

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