FGF11

Across TCGA patient cohorts, FGF11 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF11-associated genes across cancer lineages are PCNA, A-Raf_pS299, and IGFBP2. Each is linked with FGF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF11-to-partner and partner-to-FGF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FGF11-low versus FGF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF11→partner) and Y-score (partner→FGF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.245	+2.584	.015	.011	3	2
UCEC	A-Raf_pS299 →	-0.153	-2.321	.006	.034	3	1
UCEC	IGFBP2 →	-0.645	-2.584	.033	.011	3	1
UCEC	JNK2 →	+0.266	+3.009	.004	.019	3	1
UCEC	mTOR_pS2448 →	-0.181	-2.980	.009	.036	3	1
UCEC	p27_pT198 →	+0.113	+3.169	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by FGF11 expression — UCEC

Explore this box plot interactively →