FGF11

Across TCGA pan-cancer cohorts, FGF11 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FGF11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FGF11 RNA is repressed in tumor relative to normal tissue. In most cancer types FGF11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where FGF11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGF11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.010	<.001	10	view →
LUSC	Female	All	+1.149	<.001	8	view →
LUAD	Female	All	+0.439	<.001	8	view →
BLCA	Male	All	+0.809	.003	6	view →
KICH	All	All	−0.364	<.001	6	view →
BRCA	All	III,IV	−0.246	<.001	6	view →
HNSC	All	All	+0.566	<.001	5	view →
KIRC	All	III,IV	+0.327	.034	4	view →
PRAD	All	All	−0.080	<.001	2	view →
LIHC	Female	All	+0.028	.011	2	view →
CHOL	All	All	+0.350	.035	1	view →
KIRP	Male	All	−0.253	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FGF11–THCA

Open the THCA breakdown →