FGF1

Across TCGA pan-cancer cohorts, FGF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FGF1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FGF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGF1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where FGF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.204	0.834	.038	9	view →
LSCC	OS	Tertile	All	0.747	0.968	.005	7	view →
UCEC	OS	Tertile	II,III,IV	0.640	1.000	.039	4	view →
CCRCC	DFS	Quartile	All	0.922	0.667	.017	4	view →
HNSC	DFS	Tertile	III,IV	0.982	0.755	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FGF1–PDAC (DFS)

Open the PDAC breakdown →