FGF1

Across TCGA patient cohorts, FGF1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGF1-associated genes across cancer lineages are EGFR, JNK_pT183_Y185, and Ku80. Each is linked with FGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGF1-to-partner and partner-to-FGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by FGF1-low versus FGF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGF1→partner) and Y-score (partner→FGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.247	-3.321	.003	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-3.169	.011	.019	3	1
UCEC	Ku80 →	+0.274	+2.183	.026	.035	3	1
UCEC	MEK1 →	+0.434	+3.000	.023	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.249	+2.183	.021	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.567	-3.000	.016	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR by FGF1 expression — UCEC

Explore this box plot interactively →