FGD5P1

Across TCGA pan-cancer cohorts, FGD5P1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FGD5P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FGD5P1 RNA is repressed in tumor relative to normal tissue. In most cancer types FGD5P1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where FGD5P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGD5P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.053	<.001	9	view →
KICH	All	All	−0.130	<.001	7	view →
LIHC	All	III,IV	+0.020	.006	5	view →
UCEC	All	III,IV	−0.178	<.001	4	view →
BRCA	All	All	−0.166	<.001	4	view →
LUAD	Female	All	−0.065	<.001	3	view →
PRAD	All	All	−0.133	<.001	2	view →
HNSC	Female	All	−0.098	.024	2	view →
LUSC	Male	All	+0.123	.044	1	view →
KIRP	All	All	−0.056	.025	1	view →
COAD	Female	III,IV	−0.016	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FGD5P1–KIRC

Open the KIRC breakdown →