FGD5

Across TCGA pan-cancer cohorts, FGD5 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated FGD5 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FGD5 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FGD5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, LUSC, and READ are the cancer types where FGD5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	1.000	0.324	.014	20	view →
LUSC	OS	Median	III,IV	0.097	0.690	<.001	15	view →
READ	OS	Median	II,III,IV	0.487	0.821	.003	12	view →
UCEC	DFS	Median	II,III,IV	0.852	0.429	.028	10	view →
COAD	DFS	Median	All	0.927	0.497	.020	7	view →
SCLC	DFS	Median	All	1.000	0.261	.027	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CESC	OS	Median	II,III,IV	0.405	0.834	.016	4	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →
LUAD	DFS	Median	All	0.336	0.657	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

FGD5–BLCA (DFS)

Open the BLCA breakdown →