FGD5

Across TCGA pan-cancer cohorts, FGD5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FGD5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FGD5 RNA is repressed in tumor relative to normal tissue. In most cancer types FGD5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LUAD are the cancer types where FGD5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FGD5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.910	<.001	11	view →
KIRP	Male	All	−1.896	<.001	11	view →
LUAD	Female	III,IV	−2.240	<.001	9	view →
LUSC	Female	II,III,IV	−2.387	<.001	8	view →
KIRC	Female	All	+0.886	<.001	7	view →
LIHC	Female	All	+0.760	<.001	7	view →
UCEC	All	All	−2.263	<.001	6	view →
BRCA	All	All	−0.863	<.001	6	view →
HNSC	Female	III,IV	+1.048	.003	4	view →
BLCA	All	All	−0.668	.033	2	view →
THCA	All	II,III,IV	−0.521	.009	2	view →
PRAD	All	All	−0.382	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FGD5–KICH

Open the KICH breakdown →