FGD5

Across TCGA pan-cancer cohorts, FGD5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FGD5 data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FGD5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FGD5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where FGD5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.923	0.396	.006	28	view →
GBM	DFS	Median	All	0.603	0.893	.001	17	view →
LSCC	OS	Median	II,III,IV	0.881	1.000	.016	9	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FGD5–CCRCC (OS)

Open the CCRCC breakdown →