FGD5

Across TCGA patient cohorts, FGD5 mutation is significantly associated with the RNA expression of many other genes, with 6,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD5-associated genes across cancer lineages are CENPU, STIL, and TMEM186. Each is linked with FGD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both FGD5-to-partner and partner-to-FGD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by FGD5-low versus FGD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD5→partner) and Y-score (partner→FGD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.615	+1.820	<.001	<.001	3	5
COAD	STIL →	+0.486	+3.469	.005	.002	3	4
UCEC	TMEM186 →	+0.326	+1.480	.002	<.001	3	4
UCEC	CENPM →	+0.460	+1.963	<.001	<.001	3	4
UCEC	OIP5 →	+0.744	+1.809	<.001	<.001	3	4
UCEC	PIMREG →	+0.628	+1.490	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,122 associations by consensus.

CENPU by FGD5 expression — UCEC

Explore this box plot interactively →