FGD5

Across TCGA patient cohorts, FGD5 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD5-associated genes across cancer lineages are FoxM1, CDK1, and PCNA. Each is linked with FGD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both FGD5-to-partner and partner-to-FGD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FGD5-low versus FGD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD5→partner) and Y-score (partner→FGD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.154	+1.253	.028	.006	3	4
SKCM	CDK1 →	+0.167	+1.415	.001	.041	3	4
COAD	PCNA →	+0.218	+2.467	.043	.011	3	3
UCEC	Annexin_VII →	-0.087	-0.951	.021	.037	3	3
UCEC	Caspase-7-cleavedD198 →	+0.384	+1.736	.017	.001	3	3
LUAD	p70-S6K →	+0.272	+2.321	.007	.035	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

FoxM1 by FGD5 expression — UCEC

Explore this box plot interactively →