FGD5

Across TCGA cell cohorts, FGD5 mutation is significantly associated with the RNA expression of many other genes, with 1,663 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD5-associated genes across cancer lineages are CEP135, GRM6, and OR52E4. Each is linked with FGD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD5-to-partner and partner-to-FGD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP135 grouped by FGD5-low versus FGD5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD5→partner) and Y-score (partner→FGD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP135 →	+0.600	+1.850	.002	.006	3	3
BLOOD_Myeloma	GRM6 →	+0.005	+3.169	<.001	.004	3	2
SOFT_TISSUE	OR52E4 →	+0.056	+3.930	<.001	.001	3	2
BLOOD_Leukemia	ADAM29 →	+0.163	+3.270	<.001	.002	3	2
LARGE_INTESTINE	CBY1 →	+0.619	+2.451	<.001	<.001	3	2
LARGE_INTESTINE	USP14 →	+0.545	+2.546	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,663 associations by consensus.

CEP135 by FGD5 expression — LARGE_INTESTINE

Explore this box plot interactively →