FGD2

Across TCGA cell cohorts, FGD2 mutation is significantly associated with the mutation status of many other genes, with 3,630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD2-associated genes across cancer lineages are UROC1, ROBO1, and CNNM1. Each is linked with FGD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FGD2-to-partner and partner-to-FGD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UROC1 grouped by FGD2-low versus FGD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD2→partner) and Y-score (partner→FGD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UROC1 →	+3.321	+3.321	<.001	<.001	1	4
SKIN	ROBO1 →	+2.473	+3.139	.002	.002	1	4
LUNG_NSCLC_LUAD	CNNM1 →	+3.924	+5.063	.001	.001	1	3
LUNG_NSCLC_LUAD	SLIT2 →	+2.754	+4.189	.008	.008	1	3
LARGE_INTESTINE	SHPRH →	+2.032	+2.963	<.001	<.001	1	3
SKIN	FAM135B →	+2.321	+3.019	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,630 associations by consensus.

UROC1 by FGD2 expression — LARGE_INTESTINE

Explore this box plot interactively →