FGD1

Across TCGA patient cohorts, FGD1 mutation is significantly associated with the RNA expression of many other genes, with 5,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGD1-associated genes across cancer lineages are MORC4, KLRD1, and PINCR. Each is linked with FGD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FGD1-to-partner and partner-to-FGD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORC4 grouped by FGD1-low versus FGD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD1→partner) and Y-score (partner→FGD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MORC4 →	+0.836	+3.200	<.001	.009	3	3
UCEC	KLRD1 →	+0.291	+2.362	<.001	<.001	3	3
UCEC	PINCR →	+0.173	+1.480	<.001	<.001	3	3
CESC	KRT26 →	+0.556	+3.567	<.001	.004	3	2
CESC	MIR7-3 →	+0.179	+4.342	<.001	.007	3	2
CESC	SNORD115-45 →	+0.303	+4.342	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,117 associations by consensus.

MORC4 by FGD1 expression — COAD

Explore this box plot interactively →