FGD1

Across TCGA cell cohorts, FGD1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGD1-associated genes across cancer lineages are BMP15, PRM3, and GALP. Each is linked with FGD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FGD1-to-partner and partner-to-FGD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by FGD1-low versus FGD1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGD1→partner) and Y-score (partner→FGD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BMP15 →	+0.022	+5.754	<.001	.002	3	1
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.151	+3.155	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

BMP15 by FGD1 expression — CNS

Explore this box plot interactively →