FGB

Across TCGA patient cohorts, FGB mutation is significantly associated with the RNA expression of many other genes, with 1,737 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGB-associated genes across cancer lineages are SNRPBP1, RPS12P15, and MYO19. Each is linked with FGB in more than 3 cancer types. Because this analysis shows association rather than direction, both FGB-to-partner and partner-to-FGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPBP1 grouped by FGB-low versus FGB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGB→partner) and Y-score (partner→FGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRPBP1 →	+0.091	+2.476	.004	.007	3	4
COAD	RPS12P15 →	+0.168	+4.693	<.001	.007	3	2
UCEC	MYO19 →	+0.418	+2.000	.003	.003	3	2
SKCM	LINC02321 →	+1.242	+3.353	<.001	.005	3	2
UCEC	MRPS11 →	+0.471	+3.949	<.001	<.001	3	2
UCEC	TANGO2 →	+0.403	+3.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,737 associations by consensus.

SNRPBP1 by FGB expression — SKCM

Explore this box plot interactively →