FGB

Across TCGA cell cohorts, FGB mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FGB-associated genes across cancer lineages are OR1M1, SIGLEC5, and INSRR. Each is linked with FGB in more than 1 cancer types. Because this analysis shows association rather than direction, both FGB-to-partner and partner-to-FGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by FGB-low versus FGB-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGB→partner) and Y-score (partner→FGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1M1 →	+0.016	+5.643	<.001	.002	3	1
SKIN	SIGLEC5 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	INSRR →	+0.024	+3.584	.005	.007	3	1
LUNG_NSCLC_LUAD	LRRC52 →	+1.624	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L19 →	+0.005	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR1M1 by FGB expression — LUNG_SCLC

Explore this box plot interactively →