FGA

Across TCGA patient cohorts, FGA mutation is significantly associated with the RNA expression of many other genes, with 6,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FGA-associated genes across cancer lineages are MAGEA2, TXNL4A, and C16orf95. Each is linked with FGA in more than 4 cancer types. Because this analysis shows association rather than direction, both FGA-to-partner and partner-to-FGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEA2 grouped by FGA-low versus FGA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGA→partner) and Y-score (partner→FGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAGEA2 →	+0.199	+2.211	<.001	.009	3	5
UCEC	TXNL4A →	+0.376	+1.753	<.001	<.001	3	4
UCEC	C16orf95 →	+0.347	+2.285	<.001	<.001	3	4
LUSC	RPS10-NUDT3 →	+0.280	+3.368	.004	.004	2	5
UCEC	BAP1 →	+0.335	+2.285	<.001	<.001	3	4
UCEC	PXMP2 →	+0.576	+1.963	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,858 associations by consensus.

MAGEA2 by FGA expression — LUAD

Explore this box plot interactively →