FGA

Across TCGA pan-cancer cohorts, FGA RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FGA data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FGA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FGA expression acts as an unfavorable survival marker, although some lineages such as ACC and LIHC show a favorable association.

OV, LUSC, and ACC are the cancer types where FGA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	III,IV	0.303	0.399	.003	96	view →
LUSC	DFS	Median	All	0.700	0.812	<.001	66	view →
ACC	DFS	Median	II,III,IV	0.827	0.172	<.001	64	view →
LIHC	OS	Quartile	II,III,IV	0.841	0.266	<.001	53	view →
ESCA	DFS	Quartile	II,III,IV	0.623	0.380	.005	41	view →
LUAD	DFS	Quartile	All	0.694	0.833	.001	34	view →
DLBC	OS	Quartile	All	0.439	1.000	.002	29	view →
HNSC	DFS	Quartile	All	0.619	0.736	.016	17	view →
READ	OS	Median	III,IV	0.854	0.496	.014	12	view →
BRCA	OS	Quartile	IV	0.388	0.885	.004	12	view →
PRAD	DFS	Tertile	All	0.824	0.902	.014	10	view →
KIRP	DFS	Tertile	All	0.519	0.683	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FGA–OV (DFS)

Open the OV breakdown →