FGA

Across TCGA cell cohorts, FGA mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FGA-associated genes across cancer lineages are MSGN1, TOB2, and MTRNR2L6. Each is linked with FGA in more than 1 cancer types. Because this analysis shows association rather than direction, both FGA-to-partner and partner-to-FGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by FGA-low versus FGA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FGA→partner) and Y-score (partner→FGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.044	+2.345	.004	.007	3	2
LARGE_INTESTINE	TOB2 →	+0.624	+3.131	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
LARGE_INTESTINE	NEK11 →	+0.608	+3.082	.005	.007	2	2
LARGE_INTESTINE	FAHD2A →	-0.470	-3.416	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

MSGN1 by FGA expression — LARGE_INTESTINE

Explore this box plot interactively →