FEZF1

Across TCGA cell cohorts, FEZF1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FEZF1-associated genes across cancer lineages are ASB10, DEFB108B, and OR8B8. Each is linked with FEZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEZF1-to-partner and partner-to-FEZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB10 grouped by FEZF1-low versus FEZF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZF1→partner) and Y-score (partner→FEZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB10 →	+0.079	+4.551	<.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.127	+5.269	<.001	<.001	3	1
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	ACTRT1 →	+0.015	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TGM7 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP4-5 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASB10 by FEZF1 expression — BLOOD_Leukemia

Explore this box plot interactively →