FEZ2

Across TCGA cell cohorts, FEZ2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FEZ2-associated genes across cancer lineages are CDX4, C10orf53, and TAFA1. Each is linked with FEZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FEZ2-to-partner and partner-to-FEZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDX4 grouped by FEZ2-low versus FEZ2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEZ2→partner) and Y-score (partner→FEZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.151	+3.155	<.001	.008	3	1
LARGE_INTESTINE	MYMX →	+0.348	+3.426	<.001	.007	3	1
LARGE_INTESTINE	NUTM1 →	+0.066	+3.409	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CDX4 by FEZ2 expression — LARGE_INTESTINE

Explore this box plot interactively →