FEV

Across TCGA cell cohorts, FEV RNA expression is significantly associated with the go_rna of many other GO terms, with 1,600 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FEV-associated GO terms across cancer lineages are Nuclear-transcribed mRNA catabolic process, Regulation of proteasomal protein catabolic process, and Positive regulation of translation. Each is linked with FEV in more than 4 cancer types. Because this analysis shows association rather than direction, both FEV-to-partner and partner-to-FEV results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear-transcribed mRNA catabolic process grouped by FEV-low versus FEV-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FEV→partner) and Y-score (partner→FEV) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Nuclear-transcribed mRNA catabolic process →	+0.065	+0.062	<.001	.006	2	5
LUNG_SCLC	Regulation of proteasomal protein catabolic process →	+0.059	+1.574	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	Positive regulation of translation →	+0.065	+0.020	<.001	.006	3	4
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.099	+1.280	<.001	.009	2	5
BONE	T cell activation →	-0.085	-1.906	<.001	.005	3	4
BONE	Positive regulation of DNA recombination →	+0.081	+1.323	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,600 associations by consensus.

Nuclear-transcribed mRNA catabolic process by FEV expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →