FERD3L

Across TCGA patient cohorts, FERD3L mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FERD3L-associated genes across cancer lineages are MSH2, Rad50, and C-Raf. Each is linked with FERD3L in more than 1 cancer types. Because this analysis shows association rather than direction, both FERD3L-to-partner and partner-to-FERD3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by FERD3L-low versus FERD3L-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FERD3L→partner) and Y-score (partner→FERD3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSH2 →	+0.289	+2.186	.035	.034	3	2
LUAD	Rad50 →	+0.194	+3.075	.008	.016	3	2
UCEC	C-Raf →	+0.149	+2.115	.005	.017	3	2
LUAD	MSH6 →	+0.423	+3.321	.004	.010	3	1
LUAD	Rb_pS807_S811 →	-0.417	-3.000	.015	.035	3	1
UCEC	14-3-3_beta →	-0.117	-2.558	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MSH2 by FERD3L expression — LUAD

Explore this box plot interactively →