FER1L4

Across TCGA pan-cancer cohorts, FER1L4 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FER1L4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FER1L4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FER1L4 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where FER1L4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FER1L4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.649	<.001	12	view →
COAD	Female	All	+1.560	<.001	10	view →
THCA	All	II,III,IV	+0.848	<.001	10	view →
LUAD	Female	III,IV	+1.838	<.001	9	view →
BLCA	All	III,IV	+2.125	.007	7	view →
KIRP	All	II,III,IV	+1.173	<.001	7	view →
HNSC	All	All	+0.343	<.001	7	view →
LIHC	All	All	+0.336	<.001	7	view →
UCEC	All	All	+1.297	<.001	6	view →
CHOL	All	All	+2.786	<.001	5	view →
LUSC	Male	All	+0.909	<.001	5	view →
PAAD	All	All	+3.790	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FER1L4–KIRC

Open the KIRC breakdown →