FEM1C

Across TCGA patient cohorts, FEM1C mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FEM1C-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and PEA-15. Each is linked with FEM1C in more than 1 cancer types. Because this analysis shows association rather than direction, both FEM1C-to-partner and partner-to-FEM1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FEM1C-low versus FEM1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1C→partner) and Y-score (partner→FEM1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+1.584	.042	.019	3	2
UCEC	p62 Lck ligand →	+0.355	+2.916	.002	<.001	3	2
UCEC	PEA-15 →	+0.170	+2.321	.012	.033	3	2
UCEC	14-3-3_beta →	-0.099	-2.432	.006	.018	3	1
UCEC	EGFR_pY1068 →	-0.278	-2.222	.002	.010	3	1
UCEC	ER-alpha_pS118 →	-0.272	-2.321	.035	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by FEM1C expression — UCEC

Explore this box plot interactively →