FEM1C

Across TCGA pan-cancer cohorts, FEM1C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FEM1C data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FEM1C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FEM1C expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

LGG, KICH, and UVM are the cancer types where FEM1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.367	0.529	<.001	53	view →
KICH	DFS	Median	II,III,IV	0.570	0.920	.005	51	view →
UVM	DFS	Tertile	II,III,IV	0.317	0.774	.005	44	view →
KIRC	DFS	Quartile	All	0.874	0.691	.006	38	view →
PAAD	OS	Tertile	All	0.232	0.660	<.001	34	view →
READ	OS	Median	II,III,IV	0.962	0.300	.001	34	view →
COAD	OS	Tertile	II,III,IV	0.945	0.801	.013	26	view →
PRAD	DFS	Tertile	All	0.972	0.902	<.001	18	view →
DLBC	DFS	Median	All	0.629	1.000	.017	13	view →
BLCA	DFS	Quartile	II,III,IV	0.719	0.517	.002	11	view →
KIRP	DFS	Median	All	0.810	0.902	.018	10	view →
SCLC	OS	Quartile	II,III,IV	0.296	0.527	.044	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FEM1C–LGG (OS)

Open the LGG breakdown →