FEM1C

Across TCGA cell cohorts, FEM1C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,317 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FEM1C-associated GO terms across cancer lineages are Negative regulation of protein depolymerization, Regulation of extrinsic apoptotic signaling pathway via death domain receptors, and Regulation of intracellular transport. Each is linked with FEM1C in more than 11 cancer types. Because this analysis shows association rather than direction, both FEM1C-to-partner and partner-to-FEM1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein depolymerization grouped by FEM1C-low versus FEM1C-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1C→partner) and Y-score (partner→FEM1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of protein depolymerization →	+0.140	+0.833	<.001	.001	3	12
BLOOD_Lymphoma	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.122	+1.003	<.001	<.001	3	11
BONE	Regulation of intracellular transport →	+0.081	+0.790	<.001	<.001	3	11
BONE	Endocytic recycling →	+0.094	+0.950	<.001	<.001	3	11
KIDNEY	Amino acid metabolic process →	-0.071	-1.088	<.001	<.001	3	11
SOFT_TISSUE	Regulation of intracellular protein transport →	+0.073	+0.817	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,317 associations by consensus.

Negative regulation of protein depolymerization by FEM1C expression — BONE

Explore this box plot interactively →