FEM1C

Across TCGA cell cohorts, FEM1C mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FEM1C-associated genes across cancer lineages are CCDC54, COX6A2, and FBXO40. Each is linked with FEM1C in more than 1 cancer types. Because this analysis shows association rather than direction, both FEM1C-to-partner and partner-to-FEM1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC54 grouped by FEM1C-low versus FEM1C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FEM1C→partner) and Y-score (partner→FEM1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC54 →	+0.175	+3.736	<.001	.004	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FBXO40 →	+0.006	+3.882	<.001	.001	3	1
LARGE_INTESTINE	OR52A5 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	NPAP1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KRTAP21-2 →	+0.057	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CCDC54 by FEM1C expression — LARGE_INTESTINE

Explore this box plot interactively →