FDXR

Across TCGA pan-cancer cohorts, FDXR mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FDXR data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FDXR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FDXR expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and HNSC are the cancer types where FDXR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.885	.036	36	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.810	.010	11	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FDXR–COAD (DFS)

Open the COAD breakdown →