FDPS

Across TCGA patient cohorts, FDPS mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FDPS-associated genes across cancer lineages are MEK1, EGFR, and JNK_pT183_Y185. Each is linked with FDPS in more than 1 cancer types. Because this analysis shows association rather than direction, both FDPS-to-partner and partner-to-FDPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FDPS-low versus FDPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDPS→partner) and Y-score (partner→FDPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.373	+2.321	.016	.034	3	2
UCEC	EGFR →	-0.233	-3.143	<.001	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-2.459	.029	.019	3	1
UCEC	Notch1 →	+0.180	+3.472	.002	.002	3	1
UCEC	PCNA →	+0.223	+2.222	.014	.011	3	1
UCEC	PDCD4 →	-0.589	-1.700	.003	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by FDPS expression — UCEC

Explore this box plot interactively →