FDCSP

Across TCGA patient cohorts, FDCSP mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FDCSP-associated genes across cancer lineages are EGFR_pY1068, JNK2, and Smac. Each is linked with FDCSP in more than 1 cancer types. Because this analysis shows association rather than direction, both FDCSP-to-partner and partner-to-FDCSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FDCSP-low versus FDCSP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FDCSP→partner) and Y-score (partner→FDCSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.341	-3.321	.009	.010	3	1
UCEC	JNK2 →	+0.280	+3.009	.007	.019	3	1
UCEC	Smac →	+0.309	+3.000	.024	.036	3	1
UCEC	STAT3_pY705 →	-0.506	-3.169	<.001	.018	3	1
UCEC	TFRC →	+0.645	+3.321	.020	.010	3	1
UCEC	Tuberin →	+0.358	+2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by FDCSP expression — UCEC

Explore this box plot interactively →