FDCSP

Across TCGA pan-cancer cohorts, FDCSP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FDCSP’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where FDCSP RNA is repressed in tumor relative to normal tissue. In most cancer types FDCSP is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

BRCA, COAD, and LUAD are the cancer types where FDCSP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FDCSP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−3.040	<.001	8	view →
COAD	All	II,III,IV	−2.364	<.001	8	view →
LUAD	Female	All	+2.510	<.001	7	view →
STAD	All	All	+2.448	<.001	6	view →
BLCA	All	All	−1.507	.026	5	view →
HNSC	All	II,III,IV	−2.215	.012	4	view →
KIRC	All	All	+0.660	.010	4	view →
LUSC	All	All	+1.532	.007	3	view →
CHOL	All	All	+4.514	.001	2	view →
THCA	All	All	−1.821	.001	2	view →
LIHC	All	All	+0.702	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FDCSP–BRCA

Open the BRCA breakdown →