FCRL4

Across TCGA patient cohorts, FCRL4 mutation is significantly associated with the RNA expression of many other genes, with 4,843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCRL4-associated genes across cancer lineages are HMGB2, ARHGAP33, and ALKBH6. Each is linked with FCRL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FCRL4-to-partner and partner-to-FCRL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB2 grouped by FCRL4-low versus FCRL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL4→partner) and Y-score (partner→FCRL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB2 →	+0.595	+3.708	.004	<.001	3	4
UCEC	ARHGAP33 →	+0.730	+2.928	<.001	<.001	3	4
SKCM	ALKBH6 →	+0.233	+1.954	.003	.002	3	4
SKCM	CLASRP →	+0.305	+1.662	<.001	.001	3	4
UCEC	CWC25 →	+0.458	+2.354	<.001	<.001	3	3
SKCM	HNRNPA3P10 →	+0.137	+1.784	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,843 associations by consensus.

HMGB2 by FCRL4 expression — UCEC

Explore this box plot interactively →