FCRL4

Across TCGA pan-cancer cohorts, FCRL4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FCRL4 data layer compared with 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FCRL4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FCRL4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where FCRL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.672	0.537	<.001	144	view →
SKCM	OS	Median	All	0.404	0.283	<.001	63	view →
LUAD	DFS	Median	All	0.846	0.736	<.001	44	view →
KIRP	DFS	Quartile	All	0.717	0.882	.001	43	view →
BLCA	DFS	Tertile	All	0.431	0.252	.005	38	view →
ESCA	DFS	Quartile	II,III,IV	0.521	0.257	.004	25	view →
CESC	OS	Quartile	All	0.915	0.686	<.001	24	view →
KIRC	DFS	Median	All	0.497	0.723	.001	24	view →
LIHC	OS	Tertile	III,IV	0.339	0.675	.002	15	view →
STAD	DFS	Quartile	All	0.410	0.651	.006	14	view →
LAML	DFS	Tertile	All	0.796	0.462	.006	14	view →
CHOL	DFS	Quartile	All	0.680	0.245	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FCRL4–HNSC (DFS)

Open the HNSC breakdown →