FCRL4

Across TCGA cell cohorts, FCRL4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible FCRL4-associated genes across cancer lineages are CLEC10A, H2AP, and OR5K1. Each is linked with FCRL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCRL4-to-partner and partner-to-FCRL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC10A grouped by FCRL4-low versus FCRL4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCRL4→partner) and Y-score (partner→FCRL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLEC10A →	+0.007	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	H2AP →	+0.156	+4.481	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR5K1 →	+0.022	+4.093	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	SPINK8 →	+0.127	+4.736	<.001	.009	3	1
LUNG_SCLC	CST9L →	+0.036	+4.058	<.001	.007	3	1
LUNG_SCLC	MRGPRX1 →	+0.129	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CLEC10A by FCRL4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →