FCN3

Across TCGA cell cohorts, FCN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,402 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible FCN3-associated GO terms across cancer lineages are Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, Regulation of pattern recognition receptor signaling pathway, and Regulation of myoblast fusion. Each is linked with FCN3 in more than 8 cancer types. Because this analysis shows association rather than direction, both FCN3-to-partner and partner-to-FCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by FCN3-low versus FCN3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN3→partner) and Y-score (partner→FCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.110	+0.248	.003	.002	3	9
STOMACH	Regulation of pattern recognition receptor signaling pathway →	+0.064	+0.171	.001	.002	3	8
OESOPHAGUS	Regulation of myoblast fusion →	+0.132	+0.218	<.001	.001	3	7
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.151	+0.236	<.001	<.001	3	7
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.151	+0.225	<.001	<.001	3	7
OESOPHAGUS	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.072	+0.274	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,402 associations by consensus.

Negative regulation of cytoplasmic pattern recognition receptor signaling pathway by FCN3 expression — OESOPHAGUS

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