FCN3

Across TCGA pan-cancer cohorts, FCN3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FCN3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FCN3 RNA is repressed in tumor relative to normal tissue. In most cancer types FCN3 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and COAD are the cancer types where FCN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−5.338	<.001	11	view →
KIRP	Male	II,III,IV	−2.686	<.001	11	view →
COAD	All	IV	+1.050	<.001	11	view →
HNSC	Female	II,III,IV	+0.684	<.001	11	view →
LIHC	Male	II,III,IV	−5.142	<.001	9	view →
LUSC	Female	II,III,IV	−5.714	<.001	8	view →
KIRC	Female	All	+1.962	<.001	8	view →
STAD	All	All	+0.641	<.001	8	view →
THCA	Female	II,III,IV	+0.942	<.001	6	view →
BRCA	All	III,IV	−0.680	<.001	6	view →
CHOL	Male	All	−3.765	<.001	3	view →
KICH	Male	II,III,IV	−1.911	.009	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FCN3–LUAD

Open the LUAD breakdown →