FCN3

Across TCGA cell cohorts, FCN3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FCN3-associated genes across cancer lineages are DEFA4, ACSM6, and CFHR2. Each is linked with FCN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCN3-to-partner and partner-to-FCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by FCN3-low versus FCN3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN3→partner) and Y-score (partner→FCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
SKIN	GGT2 →	+0.099	+3.920	<.001	.005	3	1
SKIN	GC →	+0.077	+4.054	<.001	.004	3	1
SKIN	OR2T4 →	+0.024	+5.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DEFA4 by FCN3 expression — LARGE_INTESTINE

Explore this box plot interactively →