FCN2

Across TCGA patient cohorts, FCN2 mutation is significantly associated with the RNA expression of many other genes, with 1,163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCN2-associated genes across cancer lineages are PLCD3, NCAPH2, and RNU6-329P. Each is linked with FCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FCN2-to-partner and partner-to-FCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCD3 grouped by FCN2-low versus FCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN2→partner) and Y-score (partner→FCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLCD3 →	+0.802	+3.191	.006	.009	3	2
UCEC	NCAPH2 →	+0.507	+2.601	.002	.006	3	2
SKCM	RNU6-329P →	+0.064	+4.228	<.001	.004	3	2
SKCM	SEPTIN7P5 →	+0.033	+2.877	<.001	.009	3	2
SKCM	CHRNA5 →	+0.501	+3.195	.008	.009	3	2
BRCA	OR13C3 →	+0.117	+5.259	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,163 associations by consensus.

PLCD3 by FCN2 expression — UCEC

Explore this box plot interactively →