FCN2

Across TCGA cell cohorts, FCN2 mutation is significantly associated with the mutation status of many other genes, with 4,797 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FCN2-associated genes across cancer lineages are SLIT2, CORIN, and NXPE1. Each is linked with FCN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FCN2-to-partner and partner-to-FCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLIT2 grouped by FCN2-low versus FCN2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCN2→partner) and Y-score (partner→FCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLIT2 →	+2.754	+4.189	.008	.008	1	4
LUNG_NSCLC_LUAD	CORIN →	+3.339	+4.662	.003	.003	1	4
BLOOD_Leukemia	NXPE1 →	+4.309	+4.560	.007	.007	1	4
BLOOD_Leukemia	LZTR1 →	+3.479	+4.932	.002	.002	1	4
SKIN	DOT1L →	+2.830	+3.548	.009	.009	1	4
LUNG_SCLC	CELSR1 →	+2.985	+3.562	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,797 associations by consensus.

SLIT2 by FCN2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →