FCMR

Across TCGA patient cohorts, FCMR mutation is significantly associated with the immune_cell of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCMR-associated genes across cancer lineages are Th2 cells, Endothelial cells, and lymphatic Endothelial cells. Each is linked with FCMR in more than 1 cancer types. Because this analysis shows association rather than direction, both FCMR-to-partner and partner-to-FCMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by FCMR-low versus FCMR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCMR→partner) and Y-score (partner→FCMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Th2 cells →	+0.249	+3.006	.011	.020	3	2
UCEC	Endothelial cells →	-0.039	-2.451	.012	.020	3	2
UCEC	lymphatic Endothelial cells →	-0.023	-2.767	.016	.003	3	2
SKCM	HSC →	-0.097	-2.968	.040	.037	3	1
UCEC	Epithelial cells →	-0.079	-1.807	.007	.028	3	1
UCEC	Erythrocytes →	+0.023	+1.807	.021	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Th2 cells by FCMR expression — SKCM

Explore this box plot interactively →