FCMR

Across TCGA cell cohorts, FCMR mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FCMR-associated genes across cancer lineages are ARR3, HSFY2, and TECRL. Each is linked with FCMR in more than 1 cancer types. Because this analysis shows association rather than direction, both FCMR-to-partner and partner-to-FCMR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARR3 grouped by FCMR-low versus FCMR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCMR→partner) and Y-score (partner→FCMR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARR3 →	+0.202	+3.482	<.001	.008	3	1
LARGE_INTESTINE	HSFY2 →	+0.011	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	MAGEB1 →	+0.156	+2.878	.002	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	AMELY →	+0.025	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ARR3 by FCMR expression — LARGE_INTESTINE

Explore this box plot interactively →