FCHO1

Across TCGA patient cohorts, FCHO1 mutation is significantly associated with the RNA expression of many other genes, with 3,957 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCHO1-associated genes across cancer lineages are CORT, RPL5P31, and TRAPPC2L. Each is linked with FCHO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FCHO1-to-partner and partner-to-FCHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORT grouped by FCHO1-low versus FCHO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCHO1→partner) and Y-score (partner→FCHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CORT →	+0.494	+2.617	<.001	<.001	3	4
LIHC	RPL5P31 →	+0.037	+4.544	.004	.009	3	3
UCEC	TRAPPC2L →	+0.430	+3.029	<.001	<.001	3	3
UCEC	ZDHHC24 →	+0.273	+1.879	.003	.004	3	3
COAD	MTND3P1 →	+0.211	+3.187	<.001	.006	3	3
SKCM	ACTL10 →	-0.615	-2.196	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,957 associations by consensus.

CORT by FCHO1 expression — UCEC

Explore this box plot interactively →