FCGR3B

Across TCGA pan-cancer cohorts, FCGR3B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FCGR3B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FCGR3B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FCGR3B is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where FCGR3B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FCGR3B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−1.371	<.001	8	view →
HNSC	All	IV	−1.171	<.001	8	view →
LSCC	Male	All	−0.696	<.001	4	view →
PDAC	Female	All	+1.198	.028	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FCGR3B–LUAD

Open the LUAD breakdown →