FCGR3B

Across TCGA patient cohorts, FCGR3B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible FCGR3B-associated genes across cancer lineages are Paxillin, Bad_pS112, and Chk1_pS345. Each is linked with FCGR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGR3B-to-partner and partner-to-FCGR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Paxillin grouped by FCGR3B-low versus FCGR3B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR3B→partner) and Y-score (partner→FCGR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Paxillin →	+0.436	+2.816	.046	.036	3	1
LUSC	Bad_pS112 →	+0.209	+2.834	.025	.035	3	1
LUSC	Chk1_pS345 →	+0.146	+2.816	.006	.036	3	1
SKCM	HER2_pY1248 →	-0.162	-2.321	.025	.035	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.597	+3.169	.029	.018	3	1
SKCM	14-3-3_epsilon →	+0.240	+3.000	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Paxillin by FCGR3B expression — LUSC

Explore this box plot interactively →