FCGR2C

Across TCGA patient cohorts, FCGR2C mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FCGR2C-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with FCGR2C in more than 1 cancer types. Because this analysis shows association rather than direction, both FCGR2C-to-partner and partner-to-FCGR2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FCGR2C-low versus FCGR2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FCGR2C→partner) and Y-score (partner→FCGR2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.999	.022	.035	3	1
UCEC	A-Raf_pS299 →	-0.129	-3.000	.020	.036	3	1
UCEC	FoxM1 →	+0.238	+2.584	.048	.011	3	1
UCEC	MEK1 →	+0.480	+2.584	.004	.011	3	1
UCEC	mTOR_pS2448 →	-0.140	-2.302	.044	.034	3	1
UCEC	p70-S6K_pT389 →	-0.244	-2.584	.005	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by FCGR2C expression — UCEC

Explore this box plot interactively →